GLOSSARY

A

Acute myeloid leukemia (AML)

Malignant disease of the hematopoietic system

Adoptive T-cell therapy

Means the treatment of patients by transfer of defined T-cells to the patient

AktG

Aktiengesetz
German Stock Corporation Act

Allogen (tissue)

(Tissue) from a different, genetically non-identical body

Antibody

Protein substance produced by the immune system as a reaction to antigens for reasons of a body’s own defence mechanisms

Antigen

Substance recognised as being foreign by the immune system

Authorised capital

Value or number of shares authorised in advance by the company’s General Meeting for the purpose of a possible capital increase against cash or non-cash contribution

Autoimmune diseases

Diseases caused by an overreaction of the immune system against the body’s own tissues

Autologous (tissue)

(Tissue) from the same body

B

B-cell epitope

Part of the antigen that is recognised by the antibody or B-cell receptor

Biopharmaceutical

Research into and development of drugs and therapies (pharmaceutics), based on biotechnology and molecular biology

Biotechnology

Research into and development of drugs and therapies (pharmaceutics), based on biotechnology and molecular biology

C

CGU

Cash-generating unit

Combination therapy

The simultaneous treatment of a patient with several therapeutic methods for the same disease

Compassionate use

Prescription of as-yet unapproved drugs in particularly severe cases where there are no treatment alternatives

Conditional capital

Capital resolved by shareholders’ resolution for the issue of stock options or convertible bonds

Consortium (for a clinical trial)

Various parties contractual joined together for carrying out a clinical trial (often an -> IIT), usually university hospitals, medical professionals, manufacturers, inventors, industrial companies and public research funders (such as the DFG, the BMBF, etc)

D

D&O insurance

Directors and officers insurance
A managers’ liability insurance effected by a company for its board members and executives

DBO

Defined benefit obligation
Value of an obligation arising from company pension scheme

Dendritic cells

Cells of the immune system specialized in antigen uptake and presentation. Dendritic cells are the most potent cells for activating a primary T cell based immune response

Drug candidate

Drug which is still at the development stage

DSMB

Data and Safety Monitoring Board
An independent group of experts that reviews data in clinical trials according to patient safety and treatment effectiveness

E

EBITDA

Earnings before interests, depreciation and amortization 
Medigene’s EBITDA is derived from the net profit/loss for the year and  does not include any taxes, financial result, foreign exchange gains or losses, share of result of associates nor amortisation or depreciation

Exploratory trials

Intended for initial clarification and classification of problem areas. They are often conducted in order to get an over-view, and thus serve as preparation for further studies

Expression (of receptors)

All necessary processes around the biosynthesis of (receptor) proteins on the basis of their genetic information

F

FDA

Food and Drug Administration
Government agency of the United States Department of Health and Human Services

Formulation

The way in which an active ingredient is combined with suitable carrier substances and excipients and the form in which it is administered

G

Gastroenterology

Gastroenterology is the branch of medicine concerned with the diagnosis, treatment and prevention of diseases of the digestive system

Genital warts

Benign, but painful and disfiguring skin tumours in the genital and anal areas

GMP

Good Manufacturing Practice
Quality assurance guidelines for production processes and environments in the manufacture of drugs

H

Haematology

Haematology is the branch of medicine concerned with the study, diagnosis, treatment, and prevention of diseases related to blood

Hepatology

Hepatology is the branch of medicine that incorporates the study of liver, gallbladder, biliary tree, and pancreas as well as management of their disorders

HGB

Handelsgesetzbuch
German Commercial Code

I

IAS

International Accounting Standards
Part of the International Financial Reporting Standards

IFRIC

International Financial Reporting Interpretations Committee

IFRS

International Financial Reporting Standards

IIT (Investigator Initiated Trial)

Non-commercial clinical trial; clinical trial of a new drug candidate that is often initiated, conducted and financed by the medical professional at university hospitals. Such trials often focus on enhancing a specific therapy for patients

Immunosuppression

Damping or turning off the function of the body's immune system

Immunotherapy

Treatment method which influences and activates the immune system

Indication

Disease; reason for the execution of a medical examination or treatment

L

Leucocytes

White blood cells

Leukapheresis

Process for collection of white blood cells (leucocytes) from a donors’ blood

Licencing

Sale or acquisition of development and/or marketing rights to a product

Liposomes

Minute, hollow globules, composed of fat molecules

M

Major histocompatibility complex (MHC)

Group of genes and proteins which are relevant in immune recognition

Mature dendritic cells

Minimal residual disease (MRD)

The stage of a tumour in which only very few isolated tumour cells are present in the patient’s body following for example surgical removal of the primary tumour or chemotherapy or radiotherapy

Monoclonal antibody

Antibodies which are produced from a single cell line and can be traced back to an individual B lymphocyte

Monocytes

Belong to the class of white blood cells and have an important function in the human immune system

N

NK (natural killer) cells

Cells of the immune system which can identify and destroy cancer cells and virally infected cells

O

Oncology

Science of tumours and tumour-related diseases

P

PCT

Patent Cooperation Treaty
International agreement under which a patent application may be filed for currently 146 countries worldwide. For the issue of a patent, this application has to be transferred to a national application at a later date

Peptide

A peptide (short protein) consists of amino acids linked together

Pharmaceutics

Science that deals with the composition, effect, development, testing, production, and dispensing of drugs

Pipeline

All of the drug candidates that are under development

Polarised cells

The patented maturation method used by Medigene to generate DC vaccines, results in dendritic cells that have the capacity to induce responses from Type helper cells, due to their phenotype and function

Preclinical

Stages of development of an active substance prior to testing in humans

Proof of Concept

Evidence of the fundamental feasibility of a plan

Proof of Principle

Evidence on the feasibility at an early stage of drug development

Prophylactic vaccine

Administered to prevent a disease, prepares the immune system for the defence against infection

Prostate Cancer

Prostate cancer is a malignant, slow-growing cancer that develops in the prostate

R

R&D

Research and development

Receptor

Protein molecule which can bind different substances

Recombinant

(Partially) artificial biomolecules are referred to as being recombinant

Resistance

Ability of an organism to withstand external influences

S

Stem cell transplantation

(Hematopoietic) Stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. It may be -> autologous (the patient's own stem cells are used) or -> allogeneic (the stem cells come from a donor)

T

T-cell activation

Pivotal step in the reaction of the body’s immune system to combat pathogens and cancer

T-cell receptor (TCR)

Receptor by which T-cells recognise antigens bound to other cells of the body

T-cells

T-cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity

TecDAX

Index of the German Stock Exchange listing the thirty major technology equities with respect to market capitalisation and order book turnover

Technology platform

Technology which is the basis for the development of different drug candidates

Therapeutic vaccine

Stimulates the immune system against acute infection or an existing tumour

V

Vaccines

Inoculants

W

WpHG

Wertpapierhandelsgesetz
German Securities Trading Act

Top